Title : Androgen receptor acetylation governs trans activation and MEKK1-induced apoptosis without affecting in vitro sumoylation and trans-repression function.

Pub. Date : 2002 May

PMID : 11971970






2 Functional Relationships(s)
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1 The AR is posttranslationally modified on lysine residues by acetylation and sumoylation. Lysine androgen receptor Homo sapiens
2 As AR lysine residue mutations that abrogate acetylation correlate with enhanced binding of the N-CoR repressor in cultured cells, the conserved AR motif may directly or indirectly regulate ligand-dependent corepressor disengagement and, thereby, ligand-dependent trans activation. Lysine androgen receptor Homo sapiens