Pub. Date : 2002 Mar
PMID : 11971858
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Antisense transfection inhibited the synthesis of the direct product of glucosylceramide synthase, glucosylceramide, and consequently G(M3) ganglioside, by MEB4 cells, reducing the concentration of G(M3) in the transfectants by up to 58%. | Gangliosides | UDP-glucose ceramide glucosyltransferase | Mus musculus |
| 2 | These findings demonstrate that stable transfection of glucosylceramide synthase antisense reduces cellular glycosphingolipid levels and reduces tumorigenicity, providing further experimental support for an enhancing role of gangliosides in tumor formation. | Gangliosides | UDP-glucose ceramide glucosyltransferase | Mus musculus |