Title : Cerivastatin, an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme a reductase, inhibits endothelial cell proliferation induced by angiogenic factors in vitro and angiogenesis in in vivo models.

Pub. Date : 2002 Apr 1

PMID : 11950701






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 It inhibits the biosynthesis of cholesterol and its precursors: farnesyl pyrophosphate and geranylgeranyl pyrophosphate (GGPP), which are involved in Ras and RhoA cell signaling, respectively. geranylgeranyl pyrophosphate ras homolog family member A Gallus gallus
2 It inhibits the biosynthesis of cholesterol and its precursors: farnesyl pyrophosphate and geranylgeranyl pyrophosphate (GGPP), which are involved in Ras and RhoA cell signaling, respectively. geranylgeranyl pyrophosphate ras homolog family member A Gallus gallus
3 These effects are reversed by GGPP, suggesting that the inhibitory effect of cerivastatin is related to RhoA inactivation. geranylgeranyl pyrophosphate ras homolog family member A Gallus gallus