Title : The use of xanthan gum in an ophthalmic liquid dosage form: rheological characterization of the interaction with mucin.

Pub. Date : 2002 Apr

PMID : 11948550






4 Functional Relationships(s)
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1 The use of xanthan gum in an ophthalmic liquid dosage form: rheological characterization of the interaction with mucin. xanthan gum LOC100508689 Homo sapiens
2 The development of an ocular dosage form containing xanthan gum and capable of interacting with mucin in the precorneal area is a challenge. xanthan gum LOC100508689 Homo sapiens
3 The precorneal mucin concentration is low and the high ionic strength of the lachrymal fluid forces xanthan gum in an ordered structure, less capable of interacting through heterotypic junctions. xanthan gum LOC100508689 Homo sapiens
4 Independent of the preparation procedure applied, a xanthan gum concentration of 1.0% (w/v) is required to obtain a measurable interaction with mucin. xanthan gum LOC100508689 Homo sapiens