Title : Inhibition of human factor IXa by human antithrombin.

Pub. Date : 1975 Dec 10

PMID : 1194266






1 Functional Relationships(s)
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1 The addition of heparin dramatically accelerates the rate of this interaction with virtually complete inhibition of Factor IXa occurring within 15 s. Sodium dodecyl sulfate gel electrophoresis of reduced and nonreduced proteins indicates that antithrombin-heparin cofactor functions as a potent inhibitor of Factor IXa by forming an undissociable complex with the enzyme which is stable in the presence of denaturing or reducing agents (or both). Sodium Dodecyl Sulfate serpin family C member 1 Homo sapiens