Title : Synthesis and biological evaluation of aroylguanidines related to amiloride as inhibitors of the human platelet Na(+)/H(+) exchanger.

Pub. Date : 2002 Jun

PMID : 11937337






1 Functional Relationships(s)
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1 Pyridine and benzene bioisosteres of amiloride were synthesized and evaluated for their inhibitory potency against the sodium-hydrogen exchanger (NHE) involved in intracellular pH regulation. Hydrogen solute carrier family 9 member C1 Homo sapiens