Title : Formation and structure of a novel enediyne-RNA base covalent adduct.

Pub. Date : 2002 Apr 3

PMID : 11916399






1 Functional Relationships(s)
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1 A novel mechanism involving adduction of the NCS-chrom C-6 radical, generated by 2-mercaptoethanol activation, to C-5 of the uracil at the U9 position of the RNA 11-mer, oxidation by dioxygen, reduction by the thiol, and subsequent dehydration is proposed for adduct formation. N-chlorosuccinimide complement C6 Homo sapiens