Title : Platelet-derived growth factor-BB-mediated glycosaminoglycan synthesis is transduced through Akt.

Pub. Date : 2002 Apr 1

PMID : 11903042






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Platelet-derived growth factor-BB-mediated glycosaminoglycan synthesis is transduced through Akt. Glycosaminoglycans AKT serine/threonine kinase 1 Homo sapiens
2 Furthermore, expression of dominant-negative Akt abrogated endogenous Akt activity, Rab3D phosphorylation and GAG synthesis, whereas expression of constitutively activated Akt stimulated Rab3D phosphorylation and GAG synthesis in the absence of PDGF-BB. Glycosaminoglycans AKT serine/threonine kinase 1 Homo sapiens
3 Furthermore, expression of dominant-negative Akt abrogated endogenous Akt activity, Rab3D phosphorylation and GAG synthesis, whereas expression of constitutively activated Akt stimulated Rab3D phosphorylation and GAG synthesis in the absence of PDGF-BB. Glycosaminoglycans AKT serine/threonine kinase 1 Homo sapiens