Title : Binding of a Pleckstrin homology domain protein to phosphoinositide in membranes: a miniaturized FRET-based assay for drug screening.

Pub. Date : 2002 Feb

PMID : 11897055






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Mutations in the Btk PH domain result in changes in its affinity for PIP(3), with higher binding leading to cell transformation in vitro and lower binding leading to antibody deficiencies in both humans and mice. pip(3) Bruton tyrosine kinase Homo sapiens