Title : Genotoxic and recombinogenic activities of the two beta-carboline alkaloids harman and harmine in Saccharomyces cerevisiae.

Pub. Date : 2002 Mar 20

PMID : 11890933






1 Functional Relationships(s)
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1 An epistatic interaction was shown between rad3-e5 and rad52-1 mutants alleles, indicating that excision-resynthesis and strand-break repair may have common steps in the repair of DNA damage induced by these alkaloids. Alkaloids TFIIH/NER complex ATP-dependent 5'-3' DNA helicase subunit RAD3 Saccharomyces cerevisiae S288C