Title : Retinoic acid-induced cell cycle arrest of human myeloid cell lines is associated with sequential down-regulation of c-Myc and cyclin E and posttranscriptional up-regulation of p27(Kip1).

Pub. Date : 2002 Mar 15

PMID : 11877298






2 Functional Relationships(s)
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1 Retinoic acid-induced cell cycle arrest of human myeloid cell lines is associated with sequential down-regulation of c-Myc and cyclin E and posttranscriptional up-regulation of p27(Kip1). Tretinoin interferon alpha inducible protein 27 Homo sapiens
2 These results thus identify a decrease in c-Myc and cyclin E levels and a posttranscriptional up-regulation of p27(Kip1) as important early changes, and position them in the complex chain of events regulating ATRA-induced cell cycle arrest of myeloid cells. Tretinoin interferon alpha inducible protein 27 Homo sapiens