Title : Increased glycosphingolipid levels in serum and aortae of apolipoprotein E gene knockout mice.

Pub. Date : 2002 Feb

PMID : 11861662






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1 Increased glycosphingolipid levels in serum and aortae of apolipoprotein E gene knockout mice. Glycosphingolipids apolipoprotein E Mus musculus
2 Here we used HPLC methods to analyze serum and aortic GSL levels in apoE-/- and C57BL/6J control mice. Glycosphingolipids apolipoprotein E Mus musculus
3 In conclusion, neutral GSL and ganglioside levels were increased in the serum and aortae of apoE-/- mice compared with controls, and this was associated with a preferential redistribution of GSL to the proatherogenic lipoprotein populations. Glycosphingolipids apolipoprotein E Mus musculus
4 In conclusion, neutral GSL and ganglioside levels were increased in the serum and aortae of apoE-/- mice compared with controls, and this was associated with a preferential redistribution of GSL to the proatherogenic lipoprotein populations. Glycosphingolipids apolipoprotein E Mus musculus
5 The apoE-/- mouse therefore represents a useful model to study the potential role of GSL metabolism in atherogenesis. Glycosphingolipids apolipoprotein E Mus musculus