Title : Activation of the c-Jun N-terminal kinase (JNK) signaling pathway is essential during PBOX-6-induced apoptosis in chronic myelogenous leukemia (CML) cells.

Pub. Date : 2002 May 24

PMID : 11856743






1 Functional Relationships(s)
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1 Pretreatment of K562 cells with the JNK inhibitor, dicoumarol, abolished PBOX-6-induced phosphorylation of c-Jun and ATF-2 and inhibited the induced apoptosis, suggesting that JNK activation is an essential component of the apoptotic pathway induced by PBOX-6. Dicumarol Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens