Title : (+)-N-3-Benzyl-nirvanol and (-)-N-3-benzyl-phenobarbital: new potent and selective in vitro inhibitors of CYP2C19.

Pub. Date : 2002 Mar

PMID : 11854139






1 Functional Relationships(s)
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1 In the present study, N-3-benzyl derivatives of nirvanol and phenobarbital were synthesized, their respective (+)- and (-)-enantiomers resolved chromatographically, and inhibitor potencies determined for these compounds toward CYP2C19 and other human liver cytochromes P450 (P450s). ethylphenylhydantoin cytochrome P450 family 2 subfamily B member 6 Homo sapiens