Title : The phosphatidylinositol 3-kinase (PI3K)-Akt pathway suppresses Bax translocation to mitochondria.

Pub. Date : 2002 Apr 19

PMID : 11842081






3 Functional Relationships(s)
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1 We found that LY294002, a PI3K inhibitor, blocked the effects of serum to prevent Bax translocation to mitochondria and that expression of an active form of PI3K suppressed staurosporine-induced Bax translocation, suggesting that PI3K activity is essential for retaining Bax in the cytoplasm. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one BCL2 associated X, apoptosis regulator Homo sapiens
2 We found that LY294002, a PI3K inhibitor, blocked the effects of serum to prevent Bax translocation to mitochondria and that expression of an active form of PI3K suppressed staurosporine-induced Bax translocation, suggesting that PI3K activity is essential for retaining Bax in the cytoplasm. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one BCL2 associated X, apoptosis regulator Homo sapiens
3 We found that LY294002, a PI3K inhibitor, blocked the effects of serum to prevent Bax translocation to mitochondria and that expression of an active form of PI3K suppressed staurosporine-induced Bax translocation, suggesting that PI3K activity is essential for retaining Bax in the cytoplasm. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one BCL2 associated X, apoptosis regulator Homo sapiens