Pub. Date : 2002 Feb
PMID : 11839560
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Nicotine and cotinine up-regulate vascular endothelial growth factor expression in endothelial cells. | Cotinine | vascular endothelial growth factor A | Homo sapiens |
| 2 | We show here, using an intact porcine common carotid artery perfusion culture model, that nicotine and cotinine, the major product of nicotine metabolism, cause a significant increase in endothelial cell VEGF expression. | Cotinine | vascular endothelial growth factor A | Homo sapiens |
| 3 | Our results showed significant increases in endothelial cell VEGF mRNA and protein levels because of nicotine and cotinine at concentrations representative of plasma concentrations seen in habitual smokers. | Cotinine | vascular endothelial growth factor A | Homo sapiens |