Title : Signalling pathways involved in the direct effects of IGFBP-5 on breast epithelial cell attachment and survival.

Pub. Date : 2002

PMID : 11835403






2 Functional Relationships(s)
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1 We have demonstrated previously that IGFBP-5 can confer survival against apoptosis induced by ceramide, C2, or a small synthetic arginine-glycine-aspartic acid (RGD)-containing peptide in a direct manner. Ceramides insulin like growth factor binding protein 5 Homo sapiens
2 These data suggest that IGFBP-5 promotes the attachment and survival of Hs578T cells by modulating the balance between ceramide and opposing survival signals. Ceramides insulin like growth factor binding protein 5 Homo sapiens