Title : Autocrine induction of the human pro-IL-1beta gene promoter by IL-1beta in monocytes.

Pub. Date : 2002 Feb 15

PMID : 11823535






2 Functional Relationships(s)
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1 Transfection studies using Spi-1 mutant constructs showed that the TATA-binding protein binding and glutamine-rich domains of Spi-1 were important for IL-1beta induction, whereas LPS induction required the proline, glutamic acid, serine, and threonine-rich domain containing serine 148 as well as the TATA-binding protein and glutamine-rich domains. Glutamine TATA-box binding protein Homo sapiens
2 Transfection studies using Spi-1 mutant constructs showed that the TATA-binding protein binding and glutamine-rich domains of Spi-1 were important for IL-1beta induction, whereas LPS induction required the proline, glutamic acid, serine, and threonine-rich domain containing serine 148 as well as the TATA-binding protein and glutamine-rich domains. Glutamine TATA-box binding protein Homo sapiens