Title : Vav3 modulates B cell receptor responses by regulating phosphoinositide 3-kinase activation.

Pub. Date : 2002 Jan 21

PMID : 11805146






2 Functional Relationships(s)
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1 Here we report that Vav3 influences phosphoinositide 3-kinase (PI3K) function through Rac1 in that phosphatidylinositol-3,4,5-trisphosphate (PIP3) generation was attenuated by loss of Vav3 or by expression of a dominant negative form of Rac1. PIP3 Rac family small GTPase 1 Homo sapiens
2 Here we report that Vav3 influences phosphoinositide 3-kinase (PI3K) function through Rac1 in that phosphatidylinositol-3,4,5-trisphosphate (PIP3) generation was attenuated by loss of Vav3 or by expression of a dominant negative form of Rac1. PIP3 Rac family small GTPase 1 Homo sapiens