Title : Direct and indirect inhibition of Th1 development by progesterone and glucocorticoids.

Pub. Date : 2002 Feb 1

PMID : 11801642






2 Functional Relationships(s)
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1 Because IL-10 is known to inhibit APC production of IL-12, Th1 development may be also suppressed indirectly by progesterone. Progesterone negative elongation factor complex member C/D Homo sapiens
2 The p38 mitogen-activated protein kinase (MAPK) inhibitor SB203580 inhibited Th1 development and enhanced Th2 development, as did progesterone, indicating that p38 MAPK and extracellular signal-regulated kinase pathways are involved in Th1 development. Progesterone negative elongation factor complex member C/D Homo sapiens