Title : Stereospecific antitumor activity of radicicol oxime derivatives.

Pub. Date : 2001 Dec

PMID : 11800023






1 Functional Relationships(s)
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1 CONCLUSIONS: These results suggest that inhibition of hsp90 function, which causes depletion of hsp90 client proteins in tumor, contributes to the antitumor activity of KF58333, and that the stereochemistry of the oxime moiety is important for the biological activity of radicicol oxime derivatives. Oximes heat shock protein 90 alpha family class A member 1 Homo sapiens