Title : The role of phosphatidylinositol 3-kinase, rho family GTPases, and STAT3 in Ros-induced cell transformation.

Pub. Date : 2002 Mar 29

PMID : 11799110






3 Functional Relationships(s)
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1 Finally, we found that overexpressing a constitutively active mutant of STAT3 (STAT3C) conferred a resistance to the inhibition of Ros-induced anchorage-independent growth by LY294002, suggesting a possible overlap of functions between PI3K and STAT3 signaling in mediating Ros-induced anchorage-independent growth. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one signal transducer and activator of transcription 3 Mus musculus
2 Finally, we found that overexpressing a constitutively active mutant of STAT3 (STAT3C) conferred a resistance to the inhibition of Ros-induced anchorage-independent growth by LY294002, suggesting a possible overlap of functions between PI3K and STAT3 signaling in mediating Ros-induced anchorage-independent growth. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one signal transducer and activator of transcription 3 Mus musculus
3 Finally, we found that overexpressing a constitutively active mutant of STAT3 (STAT3C) conferred a resistance to the inhibition of Ros-induced anchorage-independent growth by LY294002, suggesting a possible overlap of functions between PI3K and STAT3 signaling in mediating Ros-induced anchorage-independent growth. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one signal transducer and activator of transcription 3 Mus musculus