Title : Mutations in the yeast LCB1 and LCB2 genes, including those corresponding to the hereditary sensory neuropathy type I mutations, dominantly inactivate serine palmitoyltransferase.

Pub. Date : 2002 Mar 22

PMID : 11781309






1 Functional Relationships(s)
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1 Furthermore, mutations in this lysine and in a histidine residue that is also predicted to be important for pyridoxal 5"-phosphate binding to Lcb2p also dominantly inactivate SPT similar to the hereditary sensory neuropathy type 1-like mutations in Lcb1p. Histidine serine C-palmitoyltransferase LCB1 Saccharomyces cerevisiae S288C