Title : [Effect of antisense oligonucleotides on endothelin converting enzyme expression and endothlin-1 release from airway smooth muscle cells].

Pub. Date : 1999 May

PMID : 11775854






2 Functional Relationships(s)
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1 CONCLUSIONS: Abnormal expression of ECE mRNA may be a keypoint responsible for TNF-alpha induced ET-1 release in human ASMC; TNF-alpha induced ET-1 release and ECE mRNA expression from human ASMC are inhibited by antisense oligonucleotide of ECE. asmc tumor necrosis factor Homo sapiens
2 CONCLUSIONS: Abnormal expression of ECE mRNA may be a keypoint responsible for TNF-alpha induced ET-1 release in human ASMC; TNF-alpha induced ET-1 release and ECE mRNA expression from human ASMC are inhibited by antisense oligonucleotide of ECE. asmc tumor necrosis factor Homo sapiens