Title : Elimination of hydrocortisone from the medium enables tissue plasminogen activator gene expression by normal and immortalized nonmalignant human epithelial cells.

Pub. Date : 2001 Nov

PMID : 11767946






5 Functional Relationships(s)
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1 Elimination of hydrocortisone from the medium enables tissue plasminogen activator gene expression by normal and immortalized nonmalignant human epithelial cells. Hydrocortisone chromosome 20 open reading frame 181 Homo sapiens
2 We found that hydrocortisone diminished tissue plasminogen activator (tPA) production to an undetectable level. Hydrocortisone chromosome 20 open reading frame 181 Homo sapiens
3 We found that hydrocortisone diminished tissue plasminogen activator (tPA) production to an undetectable level. Hydrocortisone chromosome 20 open reading frame 181 Homo sapiens
4 The removal of hydrocortisone increased urokinase plasminogen activator (uPA) activity within 24-48 h and tPA activity within 48-72 h, and converted the cells to a more elongated and fibroblastic phenotype. Hydrocortisone chromosome 20 open reading frame 181 Homo sapiens
5 The omission of hydrocortisone increased tPA levels significantly in BEAS-2B cell cultures, and in NHBE cell cultures tPA became detectable at 72 h. No PA complexes were seen in these two cell types. Hydrocortisone chromosome 20 open reading frame 181 Homo sapiens