Pub. Date : 2001 Nov
PMID : 11764287
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In XPA-deficient mice, the amount of PGE2 and the expression level of COX-2 mRNA greatly increased after UVB irradiation compared with wild-type mice. | Dinoprostone | xeroderma pigmentosum, complementation group A | Mus musculus |
| 2 | These results suggest that the excess DNA photoproducts remaining in XPA-deficient cells after UV radiation induce COX-2 expression and subsequently produce a high amount of PGE2, which causes the enhancement of inflammation and immunosuppression. | Dinoprostone | xeroderma pigmentosum, complementation group A | Mus musculus |