Pub. Date : 2001 Nov
PMID : 11763166
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Studies on pemetrexed have concluded that not only is the compound a TS inhibitor but also a potent inhibitor of human dihydrofolate reductase (DHFR). | Pemetrexed | dihydrofolate reductase | Homo sapiens |
| 2 | Studies on pemetrexed have concluded that not only is the compound a TS inhibitor but also a potent inhibitor of human dihydrofolate reductase (DHFR). | Pemetrexed | dihydrofolate reductase | Homo sapiens |
| 3 | Other studies in which the 4-oxo group of the pyrimidine ring portion of pemetrexed was replaced with a hydrogen atom, demonstrated that the resulting analogs were potent DHFR inhibitors with very little activity against the enzymes glycinamide ribonucleotide formyltransferase (GARFT) and TS [310674]. | Pemetrexed | dihydrofolate reductase | Homo sapiens |