Title : Effect of low dose tamoxifen on the insulin-like growth factor system in healthy women.

Pub. Date : 2001 Sep

PMID : 11759825






3 Functional Relationships(s)
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1 We have recently shown a comparable activity of lower doses of tamoxifen on several surrogate biomarkers of cardiovascular disease and breast cancer, including Insulin-like Growth Factor-I (IGF-I). Tamoxifen insulin like growth factor 1 Homo sapiens
2 We have recently shown a comparable activity of lower doses of tamoxifen on several surrogate biomarkers of cardiovascular disease and breast cancer, including Insulin-like Growth Factor-I (IGF-I). Tamoxifen insulin like growth factor 1 Homo sapiens
3 Compared with placebo, tamoxifen induced a mean +/- standard error (SE) reduction of IGF-I of 16.9 +/- 7.8%, p < 0.05, a non-significant increase of 22.9 +/- 12.2% in IGF-II, an increase in IGFBP-1 of 49.3 +/- 22.7%, p < 0.05, and a non-significant change of IGFBP-3 (-4.0% +/- 9.2). Tamoxifen insulin like growth factor 1 Homo sapiens