Title : Interaction between metabotropic and NMDA subtypes of glutamate receptors in sprout suppression at young synapses.

Pub. Date : 2002 Jan 1

PMID : 11756506






3 Functional Relationships(s)
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1 Calcium imaging with fluo-3 AM and morphological analyses after exposure to glutamate receptor antagonists show that a combination of AMPA/KA receptor and type II mGluR blockers mimics the decrease in intracellular free calcium in response to glutamate and the structural effects produced by NMDA receptor antagonists in these cultures. Calcium glutamate ionotropic receptor NMDA type subunit 1 L homeolog Xenopus laevis
2 Calcium imaging with fluo-3 AM and morphological analyses after exposure to glutamate receptor antagonists show that a combination of AMPA/KA receptor and type II mGluR blockers mimics the decrease in intracellular free calcium in response to glutamate and the structural effects produced by NMDA receptor antagonists in these cultures. Calcium glutamate ionotropic receptor NMDA type subunit 1 L homeolog Xenopus laevis
3 Patch-clamp analyses confirmed a decrease in NMDA receptor-mediated currents with type II mGluR blockade, and 8-bromo cAMP application produced a decrease in NMDA receptor-mediated calcium influx. Calcium glutamate ionotropic receptor NMDA type subunit 1 L homeolog Xenopus laevis