Pub. Date : 2002 Jan
PMID : 11756245
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Black tea polyphenols inhibit IGF-I-induced signaling through Akt in normal prostate epithelial cells and Du145 prostate carcinoma cells. | Polyphenols | insulin like growth factor 1 | Homo sapiens |
| 2 | Pre-treatment of PrEC and Du145 cells with doses as low as 20 microg/ml of a mixture of black tea polyphenols (BTP) substantially reduced IGF-I-mediated Akt phosphorylation. | Polyphenols | insulin like growth factor 1 | Homo sapiens |
| 3 | Our results indicate that polyphenols from black tea inhibit the IGF-I signal transduction pathway, which has been linked to increased prostate cancer incidence in human populations and, therefore, provide further support for the potential of BTP to prevent prostate cancer. | Polyphenols | insulin like growth factor 1 | Homo sapiens |