Title : Frequent detection of T cells with mutations of the hypoxanthine-guanine phosphoribosyl transferase gene in patients with paroxysmal nocturnal hemoglobinuria.

Pub. Date : 2002 Jan 1

PMID : 11756148






5 Functional Relationships(s)
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1 This study sought to test this hypothesis by examining the frequency of hypoxanthine-guanine phosphoribosyl transferase (HPRT) gene mutations, identified by both resistance to 6-thioguanine (6-TG) and gene analysis. Thioguanine hypoxanthine phosphoribosyltransferase 1 Homo sapiens
2 This study sought to test this hypothesis by examining the frequency of hypoxanthine-guanine phosphoribosyl transferase (HPRT) gene mutations, identified by both resistance to 6-thioguanine (6-TG) and gene analysis. Thioguanine hypoxanthine phosphoribosyltransferase 1 Homo sapiens
3 This study sought to test this hypothesis by examining the frequency of hypoxanthine-guanine phosphoribosyl transferase (HPRT) gene mutations, identified by both resistance to 6-thioguanine (6-TG) and gene analysis. Thioguanine hypoxanthine phosphoribosyltransferase 1 Homo sapiens
4 This study sought to test this hypothesis by examining the frequency of hypoxanthine-guanine phosphoribosyl transferase (HPRT) gene mutations, identified by both resistance to 6-thioguanine (6-TG) and gene analysis. Thioguanine hypoxanthine phosphoribosyltransferase 1 Homo sapiens
5 Unlike PNH cells, 6-TG-resistant cells expressed CD59, indicating that the HPRT mutations did not occur in PNH clones. Thioguanine hypoxanthine phosphoribosyltransferase 1 Homo sapiens