Title : Activation of peroxisome proliferator-activated receptor isoforms and inhibition of prostaglandin H(2) synthases by ibuprofen, naproxen, and indomethacin.

Pub. Date : 2001 Dec 15

PMID : 11755111






1 Functional Relationships(s)
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1 On PGHS-2, the ibuprofen isomers showed no selectivity, and indomethacin, S(+)-ibuprofen, and S(+)-naproxen were 6-, 27-, and 5-fold more potent as inhibitors of PGHS-1 than PGHS-2 activity. Naproxen prostaglandin-endoperoxide synthase 1 Rattus norvegicus