Title : p53 enhances the fidelity of DNA synthesis by human immunodeficiency virus type 1 reverse transcriptase.

Pub. Date : 2001 Nov 15

PMID : 11753641






2 Functional Relationships(s)
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1 Analysis of mispair excision opposite the template adenine residue shows that p53 catalyzes 3" terminal mismatch excision with a specificity of A : G>A : A>A : C. Hence, the observed specificity of mismatch excision indicates that p53 exonucleolytic proofreading preferentially repairs transversion mutations. Adenine tumor protein p53 Homo sapiens
2 Analysis of mispair excision opposite the template adenine residue shows that p53 catalyzes 3" terminal mismatch excision with a specificity of A : G>A : A>A : C. Hence, the observed specificity of mismatch excision indicates that p53 exonucleolytic proofreading preferentially repairs transversion mutations. Adenine tumor protein p53 Homo sapiens