Title : Ligands have various potential effects on the degradation of pregnane X receptor by proteasome.

Pub. Date : 2002 Jan

PMID : 11751591






1 Functional Relationships(s)
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1 In our recent experiments, we found that mouse pregnane X receptor (PXR) interacted with suppressor for gal1 (SUG1), a component of the proteasome, in a progesterone-dependent manner, but that endocrine-disrupting chemicals (EDCs), phthalic acid and nonylphenol, which activated PXR-mediated transcription, did not enhance this interaction. Progesterone lectin, galactose binding, soluble 1 Mus musculus