Title : Prolonged nuclear retention of activated extracellular signal-regulated protein kinase promotes cell death generated by oxidative toxicity or proteasome inhibition in a neuronal cell line.

Pub. Date : 2002 Feb 8

PMID : 11726647






2 Functional Relationships(s)
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1 Furthermore, activated ERK-1/2 is retained within the nucleus in glutamate- and MG132-treated HT22 cells. Glutamic Acid mitogen-activated protein kinase 3 Mus musculus
2 Although previous studies suggested that ERK-1/2 activation was downstream of many cell death-inducing signals in HT22 cells, we show here that cycloheximide, the Z-vad caspase inhibitor, and a nonlethal heat shock protect against glutamate- and MG132-induced toxicity without diminishing ERK-1/2 activation. Glutamic Acid mitogen-activated protein kinase 3 Mus musculus