Title : [Mode of action of clonidine, a central hypotensive agent, analyzed by the interaction with various sympathomimetic agents].

Pub. Date : 1975 Apr

PMID : 1171051






3 Functional Relationships(s)
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1 The isolated guinea-pig vas deferens contracted when treated with clonidine, and this contraction was inhibited in the reserpinized preparation. Clonidine arginine vasopressin Rattus norvegicus
2 Interaction between tyramine and clonidine was also seen in vitro, but it disappeared in the reserpinized, denervated or propranolol-pretreated guinea-pig vas deferens. Clonidine arginine vasopressin Rattus norvegicus
3 The contraction of the vas deferens induced by clonidine was potentiated by pretreatment with cocaine, but not by pretreatment with guanethidine, ans was inhibited by treatment with alpha-adrenergic blocking agents phentolamine and phentolame and phenoxybenzamine, but not by tolazoline. Clonidine arginine vasopressin Rattus norvegicus