Title : Roles of cytochrome P450 3A enzymes in the 2-hydroxylation of 1,4-cineole, a monoterpene cyclic ether, by rat and human liver microsomes.

Pub. Date : 2001 Oct

PMID : 11695850






1 Functional Relationships(s)
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1 1,8-Cineole</compound-id>, a structurally related monoterpene previously shown to be catalysed by CYP3A enzymes, inhibited 1,4-cineole 2-hydroxylation catalysed by human liver microsomes, whereas 1,4-cineole did not inhibit 1,8-cineole 2-hydroxylation activities. Monoterpenes cytochrome P450, family 3, subfamily a, polypeptide 62 Rattus norvegicus