Title : Aziridinyl quinone antitumor agents based on indoles and cyclopent[b]indoles: structure-activity relationships for cytotoxicity and antitumor activity.

Pub. Date : 2001 Oct 25

PMID : 11606119






1 Functional Relationships(s)
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Protein Name
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1 We conclude that aziridinyl quinones of this type should possess a substrate specificity (V(max)/K(M)) < 10 x 10(-4) s(-1) for DT-diaphorase in order not to be too toxic or nonselective. diaziquone NAD(P)H quinone dehydrogenase 1 Homo sapiens