Pub. Date : 2001 Oct 25
PMID : 11604224
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In vitro growth hormone (GH) stimulation of Janus kinase 2 (Jak2) tyrosine phosphorylation and activation has been detected in rat adipocytes where GH exerts both chronic diabetogenic and acute insulin-like effects but not in adipocytes where only chronic diabetogenic effects are exerted. | Tyrosine | gonadotropin releasing hormone receptor | Rattus norvegicus |
| 2 | In vitro growth hormone (GH) stimulation of Janus kinase 2 (Jak2) tyrosine phosphorylation and activation has been detected in rat adipocytes where GH exerts both chronic diabetogenic and acute insulin-like effects but not in adipocytes where only chronic diabetogenic effects are exerted. | Tyrosine | gonadotropin releasing hormone receptor | Rattus norvegicus |
| 3 | In vitro growth hormone (GH) stimulation of Janus kinase 2 (Jak2) tyrosine phosphorylation and activation has been detected in rat adipocytes where GH exerts both chronic diabetogenic and acute insulin-like effects but not in adipocytes where only chronic diabetogenic effects are exerted. | Tyrosine | gonadotropin releasing hormone receptor | Rattus norvegicus |
| 4 | The 95 kDa transcription factor Stat5, which is tyrosine phosphorylated in response to GH in both cases, is here identified as the 5A-isoform. | Tyrosine | gonadotropin releasing hormone receptor | Rattus norvegicus |
| 5 | However, in adipocytes where GH exerts both diabetogenic and insulin-like effects, and both Jak2 and Stat5A were activated, their phosphorylation kinetics and downregulation of tyrosine phosphorylation were almost identical. | Tyrosine | gonadotropin releasing hormone receptor | Rattus norvegicus |