Pub. Date : 2001 Dec 7
PMID : 11595732
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We found a striking difference between these cells in that while ATRA induces an elevation in the cdk inhibitor p27 in T-47D cells, this is not observed in the ATRA-resistant MCF-7 cells. | Tretinoin | interferon alpha inducible protein 27 | Homo sapiens |
| 2 | Furthermore, we demonstrate that ATRA promotes the ubiquitylation of Skp2, an F-box protein that targets p27 for degradation. | Tretinoin | interferon alpha inducible protein 27 | Homo sapiens |