Pub. Date : 2001 Oct 9
PMID : 11593040
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The PARP1 inhibitor benzamide and the PARG inhibitor gallotannin both prevented the NAD(+) depletion that otherwise results from PARP1 activation by MNNG or H(2)O(2). | NAD | poly (ADP-ribose) glycohydrolase | Mus musculus |
| 2 | These results suggest that PARG inhibitors do not inhibit PARP1 directly, but instead prevent PARP1-mediated cell death by slowing the turnover of poly(ADP-ribose) and thus slowing NAD(+) consumption. | NAD | poly (ADP-ribose) glycohydrolase | Mus musculus |