Title : Organolanthanide-catalyzed intramolecular hydroamination/cyclization of amines tethered to 1,2-disubstituted alkenes.

Pub. Date : 2001 Oct 4

PMID : 11574002






1 Functional Relationships(s)
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Protein Name
Organism
1 [Me(2)Si(eta(5)-Me(4)C(5))((t)BuN)]LnE(TMS)(2) mediates intramolecular hydroamination/cyclization of sterically demanding amino-olefins to afford disubstituted pyrrolidines in high diastereoselectivity (trans/cis = 16/1) and in good to excellent yield. Pyrrolidines PYD and CARD domain containing Homo sapiens