Title : Tertiary N-glucuronides of clozapine and its metabolite desmethylclozapine in patient urine.

Pub. Date : 2001 Oct

PMID : 11560879






2 Functional Relationships(s)
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1 In experiments with expressed human UDP-glucuronosyltransferase 1A4 (UGT1A4), the antipsychotic clozapine proved to be conjugated to two different glucuronides, one of which was identified as the quaternary ammonium glucuronide derivatized at the N-methylpiperazine group; this compound had previously been isolated from patient urine. quaternary ammonium glucuronide UDP glucuronosyltransferase family 1 member A4 Homo sapiens
2 In experiments with expressed human UDP-glucuronosyltransferase 1A4 (UGT1A4), the antipsychotic clozapine proved to be conjugated to two different glucuronides, one of which was identified as the quaternary ammonium glucuronide derivatized at the N-methylpiperazine group; this compound had previously been isolated from patient urine. quaternary ammonium glucuronide UDP glucuronosyltransferase family 1 member A4 Homo sapiens