Pub. Date : 2001 Oct
PMID : 11557524
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Multidrug resistance-associated protein 3 (MRP3), unlike other MRPs, transports taurocholate (TC). | Taurocholic Acid | ATP binding cassette subfamily C member 3 | Rattus norvegicus |
| 2 | Multidrug resistance-associated protein 3 (MRP3), unlike other MRPs, transports taurocholate (TC). | Taurocholic Acid | ATP binding cassette subfamily C member 3 | Rattus norvegicus |
| 3 | Multidrug resistance-associated protein 3 (MRP3), unlike other MRPs, transports taurocholate (TC). | Taurocholic Acid | ATP binding cassette subfamily C member 3 | Rattus norvegicus |
| 4 | Multidrug resistance-associated protein 3 (MRP3), unlike other MRPs, transports taurocholate (TC). | Taurocholic Acid | ATP binding cassette subfamily C member 3 | Rattus norvegicus |
| 5 | The difference in TC transport activity between rat MRP2 and MRP3 was studied, focusing on the cationic amino acids in the transmembrane domains. | Taurocholic Acid | ATP binding cassette subfamily C member 3 | Rattus norvegicus |
| 6 | Substitution of Leu at position 1084 of rat MRP3 (which corresponds to Arg-1096 in rat MRP2) with Lys, but not with Val or Met, resulted in the loss of transport activity for TC and glucuronide conjugates. | Taurocholic Acid | ATP binding cassette subfamily C member 3 | Rattus norvegicus |
| 7 | These results suggest that the presence of the cationic charge at Arg-586 and Arg-1096 in rat MRP2 prevents the transport of TC, whereas the presence of neutral amino acids at the corresponding position of rat MRP3 is required for the transport of substrates. | Taurocholic Acid | ATP binding cassette subfamily C member 3 | Rattus norvegicus |