Title : Evidence for glycosylation-dependent activities of polypeptide N-acetylgalactosaminyltransferases rGalNAc-T2 and -T4 on mucin glycopeptides.

Pub. Date : 2001 Sep

PMID : 11555617






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 GalNAc residues on MUC1 acceptor peptides trigger activity of rGalNAc-T4 directed to Ser in VTSA and Thr in PDTR and of rGalNAc-T2 to Ser/Thr within the GSTA motif of variant MUC1 peptides. N-acetylgalactosaminuronic acid mucin 1, cell surface associated Homo sapiens
2 GalNAc residues on MUC1 acceptor peptides trigger activity of rGalNAc-T4 directed to Ser in VTSA and Thr in PDTR and of rGalNAc-T2 to Ser/Thr within the GSTA motif of variant MUC1 peptides. N-acetylgalactosaminuronic acid mucin 1, cell surface associated Homo sapiens
3 These findings are in accord with the inhibition of rGalNAc-T2 and -T4 by fully GalNAc-substituted MUC1 repeat peptide and support a glycosylation-dependent activity induction or enhancement of both enzymes. N-acetylgalactosaminuronic acid mucin 1, cell surface associated Homo sapiens