Pub. Date : 1985
PMID : 11539696
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | DL-alpha-Difluoromethylornithine (DFMO) and DL-alpha-difluoromethylarginine (DFMA), specific, irreversible ("suicide") inhibitors of ODC and ADC in vitro, were used to modulate PA biosynthesis in excised flowers. | Eflornithine | ornithine decarboxylase | Nicotiana tabacum |
| 2 | In vivo inhibition of ODC with DFMO resulted in a significant decrease in PA titers, ovary fresh weight and protein content. | Eflornithine | ornithine decarboxylase | Nicotiana tabacum |
| 3 | Simultaneous inhibition of both decarboxylases by DFMO and DFMA produced only a marginally greater depression in growth and PA titers, indicating that ODC activity is rate-limiting for PA biosynthesis in these tissues. | Eflornithine | ornithine decarboxylase | Nicotiana tabacum |
| 4 | In vivo inhibition of ODC by DFMA appears to result from arginase-mediated hydrolysis of this inhibitor to urea and DFMO, the suicide substrate for ODC. | Eflornithine | ornithine decarboxylase | Nicotiana tabacum |
| 5 | In vivo inhibition of ODC by DFMA appears to result from arginase-mediated hydrolysis of this inhibitor to urea and DFMO, the suicide substrate for ODC. | Eflornithine | ornithine decarboxylase | Nicotiana tabacum |