Title : High affinity interleukin-3 receptor expression on blasts from patients with acute myelogenous leukemia correlates with cytotoxicity of a diphtheria toxin/IL-3 fusion protein.

Pub. Date : 2001 Oct

PMID : 11532521






6 Functional Relationships(s)
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1 We prepared DT(388)IL3 composed of human interleukin-3 (IL3) fused to the catalytic and translocation domain of diphtheria toxin (DT(388)) and assessed its activity on patient AML blasts. Thymidine interleukin 3 Homo sapiens
2 We prepared DT(388)IL3 composed of human interleukin-3 (IL3) fused to the catalytic and translocation domain of diphtheria toxin (DT(388)) and assessed its activity on patient AML blasts. Thymidine interleukin 3 Homo sapiens
3 We prepared DT(388)IL3 composed of human interleukin-3 (IL3) fused to the catalytic and translocation domain of diphtheria toxin (DT(388)) and assessed its activity on patient AML blasts. Thymidine interleukin 3 Homo sapiens
4 DT(388)IL3 cytotoxicity (>1 log cell kill) was seen in nine of 25 samples (36%). Thymidine interleukin 3 Homo sapiens
5 There was a significant correlation between DT(388)IL3 log cell kill and blast high affinity IL3 receptor density (P=0.0044). Thymidine interleukin 3 Homo sapiens
6 There was a significant correlation between DT(388)IL3 log cell kill and blast high affinity IL3 receptor density (P=0.0044). Thymidine interleukin 3 Homo sapiens