Pub. Date : 2001
PMID : 11527213
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Yap1 overproduction restores arsenite resistance to the ABC transporter deficient mutant ycf1 by activating ACR3 expression. | arsenite | Arr3p | Saccharomyces cerevisiae S288C |
| 2 | Ycf1 and Acr3 are transporters that have been previously shown to protect Saccharomyces cerevisiae cells from the toxic effects of arsenite. | arsenite | Arr3p | Saccharomyces cerevisiae S288C |
| 3 | We further show that the expression of either an ACR3-lacZ promoter fusion reporter or the endogenous ACR3 gene was stimulated by the overproduction of Yap1 upon exposure to arsenite. | arsenite | Arr3p | Saccharomyces cerevisiae S288C |
| 4 | We further show that the expression of either an ACR3-lacZ promoter fusion reporter or the endogenous ACR3 gene was stimulated by the overproduction of Yap1 upon exposure to arsenite. | arsenite | Arr3p | Saccharomyces cerevisiae S288C |
| 5 | These data suggest that Yap1 confers arsenite resistance to the ycf1 null mutant by activating expression of the Yap8-dependent target gene, ACR3. | arsenite | Arr3p | Saccharomyces cerevisiae S288C |
| 6 | Our data also show Yap8-dependent ACR3-lacZ expression was greatly stimulated by arsenite in a dose-dependent manner in the parental strain. | arsenite | Arr3p | Saccharomyces cerevisiae S288C |