Title : Bax translocation to mitochondria subsequent to a rapid loss of mitochondrial membrane potential.

Pub. Date : 2001 Sep

PMID : 11526446






2 Functional Relationships(s)
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1 The mitochondria uncoupler FCCP, in the presence of the F(1)-F(0) ATPase inhibitor oligomycin, can trigger Bax translocation to mitochondria suggesting that when ATP levels are maintained a collapse of DeltaPsi(m) induces Bax translocation. Adenosine Triphosphate BCL2 associated X, apoptosis regulator Homo sapiens
2 Bax association with mitochondria is also triggered by inhibitors of the electron transport chain, antimycin and rotenone, compounds that collapse DeltaPsi(m) without inducing rapid ATP hydrolysis that typically occurs with uncouplers such as FCCP. Adenosine Triphosphate BCL2 associated X, apoptosis regulator Homo sapiens