Title : Mitochondrial targeting of JNK/SAPK in the phorbol ester response of myeloid leukemia cells.

Pub. Date : 2001 Aug

PMID : 11526432






4 Functional Relationships(s)
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1 The results show that TPA induces the association of SAPK with the mitochondrial anti-apoptotic Bcl-x(L) protein. Tetradecanoylphorbol Acetate BCL2 like 1 Homo sapiens
2 Overexpression of Bcl-x(L) attenuated the apoptotic response to TPA treatment. Tetradecanoylphorbol Acetate BCL2 like 1 Homo sapiens
3 Moreover, expression of Bcl-x(L) mutated at sites of SAPK phosphorylation (Thr-47, -115) was more effective than wild-type Bcl-x(L) in abrogating TPA-induced cytochrome c release and apoptosis. Tetradecanoylphorbol Acetate BCL2 like 1 Homo sapiens
4 Moreover, expression of Bcl-x(L) mutated at sites of SAPK phosphorylation (Thr-47, -115) was more effective than wild-type Bcl-x(L) in abrogating TPA-induced cytochrome c release and apoptosis. Tetradecanoylphorbol Acetate BCL2 like 1 Homo sapiens